Stay up-to-date on latest anti-aging research from top longevity scientists.
Published in Nature Aging, the Universal Horvath Clock reveals the remarkable conservation of key epigenetic aging markers across all species.
Derived from an extensive body of research encompassing DNA methylation and epigenetic clocks spanning more than 180 mammalian species, ranging from majestic whales to tiny marsupials, as well as our human counterparts and beloved pets, this third-generation clock revolutionizes our understanding of aging and paves the way for cutting-edge anti-aging research.
In contrast to the prevailing model of aging predicated on the accumulation of cellular damage, the Universal Clock introduces an alternative perspective, known as the “pseudo-programmatic theory of aging.” This paradigm shift represents a potential stride toward unraveling and potentially “deprogramming” the aging process itself.
At the heart of this research is the discovery of a select number of highly conserved epigenetic age markers shared across animals. The Universal Horvath Clock is an unprecedented tool for researchers and longevity pursuers alike. This third generation epigenetic clock enables us to construct a bridge between species, connecting aging and longevity discoveries in one species to anti-aging treatments and therapies in others, including us humans. It sets the stage for cutting-edge translational anti-aging research and innovation.
Learn more in our Open Access Paper Universal DNA methylation age across mammalian tissues (2023)” in Nature Aging.
First Generation Epigenetic Clocks were the first to discover evidence that DNA methylation patterns or changes in certain epigenetic markers are linked with our age!
These clocks were trained and built to estimate our actual chronological age, irrespective of health status or health risks.
Examples of 1st Gen Clocks:
Second Generation Epigenetic Clocks were trained and built to estimate biological age and mortality risk.
These clocks were a significant improvement over so-called “first gen” clocks due their ability to predict time-to-death, their strong association with a number of age-related diseases and actionable insight into key mechanistic components of individual aging.
Examples of 2nd Gen Clocks:
Third Generation or “Universal” Epigenetic Clocks were designed to understand and unlock what is aging across different animals and enable cutting-edge translational longevity research.
Trained on data from over 180 mammalian species, 3rd Gen Clock were built to estimate one’s universal biological age based on the most conserved components of aging across species and tissue types.
3rd gen clocks help us understand our aging across different animals and enable translational medicine by linking discoveries in one species with possible longevity treatments in others including humans!
Universal Horvath Clock (2022) is currently world’s only third generation epigentic clock.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to screen, diagnose, treat, cure, or prevent any disease or condition or assess risk of any disease or condition. Unless advised by your healthcare professional, biological age should not be used to determine or alter any age-related health or medical treatments based on your chronological age.
© 2023 Clock Foundation.