ANNOUNCING: 🚀AKG Open Enrollment Longevity Group Launch

Does AKG really reverse aging by 8 years? Let's find out!

Join a Clock Foundation Open Longevity Group

Now Enrolling: Longevity Group to Study Effects of AKG (US & UK Only)

The AKG Open Enrollment Longevity Group is an initiative by the Clock Foundation designed for individuals in the US and UK who are interested in exploring the effects of Alpha-Ketoglutarate (AKG), and specifically Ca-AKG, a supplement reported to influence epigenetic aging.

The program offers a participatory research opportunity for individuals to explore the potential anti-aging effects of Ca-AKG, while contributing to a broader understanding of aging and wellness. This group facilitates a structured, six-month program where participants can monitor and analyze the impact of Ca-AKG on their aging process. Monitoring includes top longevity biomarker tests and wearables data.

Participants receive updates on their individual progress and, at the end of the study, a comprehensive report that includes both their anonymized individual results and the overall findings of the group study.

NOTE: Participants will be responsible for purchasing their own supply of Ca-AKG (not included in the program at an estimated cost of $30-$50 per month) and following the specific dosing instructions provided.

The Clock Foundation is a longevity research-oriented, non-profit based in Los Angeles, founded by Steve Horvath and Bobby Brooke. Our mission is to enable everyone to achieve longer, healthier live using safe and affordable interventions.

What’s In It For You?

What's included?

Group 1000001518 (1)
3 PhenoAge (lab-based blood plasma) age tests
Wearables Tracking for sleep, activity and stress.

Advanced Longevity Reports & Personalized Treatment Recommendations

Comprehensive Epigenetic Age and Longevity Testing Package Brought to you by the Clock Foundation

+ BioAge Monitoring Plan

+ Wearables and Health Tracking

+ Longevity Actions & Interventions Tracking

+ Interactive Reports and Web Portal

+ Group Analysis Reports, Analyzing the Overall Effects of Treatment

What you get:

  • 6-month aging monitoring plan including (3) PhenoAge Biological Age Tests (only available in US and UK)
  • Monthly Wearables and Aging Biomarker Reports: We currently support Oura, Fitbit and Google Health (with additional integrations coming soon)
  • Personalized Aging Reports: You’ll receive regular updates on your individual results, keeping you informed every step of the way.
  • Final Group Report: At the end of the study, you’ll receive a detailed report encompassing both your anonymized summary data and the overall group results.

🎁 Bonus Offers and Additional Options

  • 🏦 Discounted GrimAge Tests (up to 25% off)
  • 📊 After taking more than one test: Get a Personalized Longitudinal Report including all available clocks and detailed readout of changes over time. 
  • 🧬For Previous TestersAnalysis of Previous DNA Methylation Tests.
  • Access to a community of longevity biohackers and future open enrollment longevity programs. 

Why Join an Open Longevity Group?

Test Many Promising Treatments

Open Longevity Groups will test some of the most promising and talked about interventions.  

AKG for instance has been reported to rejuvenate epigenetic age by 8 years!  

Unfortunately, like many promising treatments, the results have never been replicated and so it’s uncertain how profound its effects really are.  With your help, we are changing that, as we’re providing a quick and convenient way to independently validate its effects.  

Monitor Your Own Biomarkers

Track your progress with the longevity tests used by top anti-aging researchers like PhenoAge and GrimAge.

Monitor your wearables data for sleep, activity, heart rate variability (HRV), stress, and more, and obtain a wearables report that includes leading aging biomarkers.

Extended epigenetics reports and longitudinal tracking reports are also available to gain more insight into your own aging process.

Accelerate Longevity Science

By participating, you’re not just exploring your own aging journey, but also contributing to the science of longevity in general. 

Your anonymized data, along with others, will form a comprehensive group outcomes analysis and help validate effects for each treatment.

Groups are intended to obtain results both rapidly and rigorously, so that we can all understand with certainty whether or not treatments live up to the hype. 

How We Measure Aging

Biological Aging Tests Developed & Used by Top Longevity Researchers

Blood Testing (PhenoAge)

Close up of hand of laboratory technician holding test tube with blood sample with another test tubes in backside on white background.
  • The PhenoAge Test is blood plasma biological age test.
  • Based on levels of 9 clinical biomarkers circulating in blood, PhenoAge has been found to strongly correlate with onset of age-related diseases and mortality.
  • Requires a simple lab-based blood test.

Epigenetic Age Testing (GrimAge)

  • GrimAge is an epigenetic age test based on DNA methylation that predict your biological age and mortality risk.
  • Developed in the Horvath lab at UCLA and validated across a wide variety of human cell types and tissues.
  • Validated as most accurate mortality predictor and provides personalized age risk factors and anti-aging recommendations.

Recent Media Coverage & Interviews

National Geographic: Can aging be cured? Scientists are giving it a try

The Guardian: Real age versus biological age

Financial Times: Can we defeat death?

Bloomberg: Will Humans Live to 150? Science Is Working on It

Quanta Magazine: Epigenetic ‘Clocks’ Predict Animals’ True Biological Age

Frequently Asked Questions

What is biological age? What is a biological age test?

Biological age refers to your age on a biological level compared to your chronological age or how many birthdays have passed for you. 

Biological age tests look at changes in your biology that are indicative of biological aging. In our case, our biological age test uses what is called an epigenetic clock to calculate your biological age.  

Fortunately, your biological age is modifiable, meaning you can change it. Tracking your biological age can help you see changes over time and understand the impact diet, lifestyles changes, and anti-aging treatments are having on your rate of aging.

What is the difference between the PhenoAge Test and the GrimAge Test?

Both tests determine biological age and associated risks.

PhenoAge is calculated using levels of 9 clinical biomarkers circulating in blood, which were found to strongly correlate with onset of age-related diseases and mortality.

GrimAge Test is an epigenetic test and predicts your biological age based on DNA methylation, basically changes in your DNA over time. GrimAge is the “gold standard” in longevity research offers and offers personalized aging drivers, risk factors and tailored recommendations for longevity.

PhenoAge Test involves a blood (plasma) lab test and takes just a few days to get your results, while a GrimAge involves an at-home blood collection kit, which you ship back to our lab for processing, DNA extracting and sequencing, and report processing. GrimAge takes a few weeks to complete and get your report.

How does testing work?

After ordering a single test or a package, you’ll receive a welcome email detailing how our program works and the steps ahead.

For U.S. participants, this initial email will include:

  1. A link to an online survey to register your test kit and complete a brief intake questionnaire;
  2. A form that enables you to obtain your first blood draw, along with instructions on how to schedule an appointment; and
  3. Instructions on how to collect and return your at-home blood collection kit.

For a PhenoAge Test, you will receive your initial test report including your  results as soon as each of the above steps have been completed (within approximately 1 week). Once you receive your initial results, you’ll also be able to book a 1-on-1 consultation with our team to discuss.

Results of our advanced Epigenetic Test are usually available within 4-6 weeks. 

How do subscriptions work? What's your cancellation policy?

Our subscription and longevity biomarker plans combine the two biological aging tests used by longevity researchers with wearable monitoring, providing cutting-edge longevity intervention tracking and aging monitoring.

Our wearables monitoring plan integrates with Oura, FitBit, Google, Garmin and an assortment of health trackers. Data is sync regularly and you’ll receive a personal month report proving HRV Age as well as sleep, activity and other aging metric.

You’ll receive access to our longevity tracking portal to review and monitor your health data and reports as well as tools to track and manage your longevity interventions and actions.

Cancellations are accepted at anytime, but in order to obtain test results from a submitted sample, it requires having an active subscription for at least 2 months to cover costs.

Where do you ship? Do you ship internationally?

We currently only ship to the United States, UK and Europe and serviced by labs in Los Angeles, USA, and Manchester, UK.

Please contact us if you are located elsewhere and are still interested in purchasing a test or participating in an anti-aging trial.

How is an epigenetic test different from a DNA test like 23andMe?

A genetic or DNA test looks at what your DNA contains whereas an epigenetic age test measures various epigenetic changes on our DNA itself. Unlike DNA, your epigenetics are modifiable.

Many cells in the body have an “epigenetic clock” that keeps track of how quickly they are aging or, more accurately, how much damage has been done since they were created.

Our test provides your biological age as well as various key drivers of your aging.

Can I use my genetic data from 23andMe, Ancestry or other genetic tests?

Our tests are based on epigenetic data. Unfortunately we are not able to compute GrimAge based from genetic data provided by Ancestry or 23&Me.  We require epigenetic data and specifically IDAT files provided by epigenetic test providers.  There are many service labs around the world who provide this type of service using testing provided by Illumina methylation arrays (such as the EPIC methylation beadchip)

What is Epigenetics?

Epigenetics is the study of how genes are turned off and on during an animal’s lifetime, including humans. 

A Greek word meaning “above genetics”, epigenetics is the study of changes in gene function that occur without detectable changes to DNA sequence. What this means is that your gene expression (like what proteins your cells produce) changes but your gene sequences themselves do not change. 

Epigenetics most often involves changes that affect gene activity and expression. These epigenetic changes can occur due to normal biological development but they can also result from external or environmental factors like food choices, stress levels or even injury.

What is the science behind these tests?

DNA methylation is a process where methyl groups are added to DNA to influence gene expression, and which are critical for normal human development, defining cell identity, as well as for rejuvenation and reprogramming.  Highly accurate estimators of chronological age have been developed are known as epigenetic aging clocks, which can predict chronological age through development and across the lifespan (Horvath 2013, Horvath & Raj 2018). 

Increasingly these clocks are also being used as a measure of biological age as certain measures – most notably GrimAge (Lu 2019, Li 2020), which is able to predict future morbidity and mortality risk.  GrimAge also performs well for predicting functional decline and onset of major age-related diseases, including heart disease, cancer onset, multi-modal measures of brain health, kidney disease, fatty liver, respiratory function, and more (Lu 2019, Hillary 2018, Hillary 2020, McCrory 2020). These peer reviewed and independent studies have also shown that it performs reliably across large diverse populations.  

Many researchers conclude today that overall epigenetic clocks now represent the most robust measure of biological age (Li 2020, Jylhava et al 2017, Justice & Kritchevsky 2020).


These statements have not been evaluated by the Food and Drug Administration. These products are not intended to screen, diagnose, treat, cure, or prevent any disease or condition or assess risk of any disease or condition. Unless advised by your healthcare professional, biological age should not be used to determine or alter any age-related health or medical treatments based on your chronological age.

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