⏳Longevity Signals📈
November 18th, 2025
Note: This is not medical advice. Please consult your physician before making changes to your health routine.
🩺 Longevity + Treatments 💪
Nicotinamide Riboside Increases NAD+ Levels in Long-COVID Trial but Doesn’t Significantly Improve Symptoms
In a long-COVID trial, the NAD+ precursor nicotinamide riboside (NR) increased NAD+ levels but did not significantly improve cognition, fatigue, sleep, or mood. Exploratory analyses suggest potential benefits after 10 weeks, indicating a need for larger trials.
In a long-COVID trial, the NAD+ precursor nicotinamide riboside (NR) increased NAD+ levels but did not significantly improve cognition, fatigue, sleep, or mood. Exploratory analyses suggest potential benefits after 10 weeks, indicating a need for larger trials.
🔬 The Impact of Ketamine Treatment on Epigenetic Aging in Patients with MDD and PTSD
Ketamine therapy reduces depression and PTSD symptoms and decreases epigenetic age according to biomarkers OMICmAge, GrimAge V2, and PhenoAge. The study suggests that ketamine may impact biological aging.
Ketamine therapy reduces depression and PTSD symptoms and decreases epigenetic age according to biomarkers OMICmAge, GrimAge V2, and PhenoAge. The study suggests that ketamine may impact biological aging.
🐁 Stem Cell Secretome Treatment Enhances Weight Loss and Metabolic Health in Obese Mice
A stem cell-derived secretome treatment reduces adiposity, improves tissue quality and metabolic health in obese mice undergoing weight loss, according to a study by researchers at the University of Utah and Immunis Inc.
A stem cell-derived secretome treatment reduces adiposity, improves tissue quality and metabolic health in obese mice undergoing weight loss, according to a study by researchers at the University of Utah and Immunis Inc.
🐁 New Alzheimer’s Therapy Targets Blood-Brain Barrier for Effective Amyloid-Beta Clearance
A new therapeutic approach targeting the blood-brain barrier (BBB) was shown to reduce amyloid-beta plaques in the brains of Alzheimer’s disease model mice by around 45%, and improve their cognitive function. The therapy works by enhancing the expression of low-density lipoprotein receptor-related protein 1 (LRP1) to promote efficient amyloid-beta removal.
A new therapeutic approach targeting the blood-brain barrier (BBB) was shown to reduce amyloid-beta plaques in the brains of Alzheimer’s disease model mice by around 45%, and improve their cognitive function. The therapy works by enhancing the expression of low-density lipoprotein receptor-related protein 1 (LRP1) to promote efficient amyloid-beta removal.
🐁Psilocybin: A Candidate Compound to Counteract Brain Aging
Psilocybin improves cognition, reduces depression-like behavior in aging mice via epigenetic regulation of genes related to neural plasticity and immune response. It reverses age-related DNA methylation, showing potential for countering brain aging.
Psilocybin improves cognition, reduces depression-like behavior in aging mice via epigenetic regulation of genes related to neural plasticity and immune response. It reverses age-related DNA methylation, showing potential for countering brain aging.
Unleashing the Potential of Aged Garlic Extract in Aging and Cardiovascular Health
Aged garlic extract (AGE) and its components, such as S-allyl cysteine and N-α-(1-deoxy-D-fructos-1-yl)-L-arginine, could potentially slow down aging-related cognitive decline and mitigate cardiovascular health risks. Findings from animal studies and human trials suggest beneficial effects on arterial elasticity, inflammation, ventricular mass, and atherosclerosis progression.
Aged garlic extract (AGE) and its components, such as S-allyl cysteine and N-α-(1-deoxy-D-fructos-1-yl)-L-arginine, could potentially slow down aging-related cognitive decline and mitigate cardiovascular health risks. Findings from animal studies and human trials suggest beneficial effects on arterial elasticity, inflammation, ventricular mass, and atherosclerosis progression.
Vitamin B12 Deficiency: An Underdiagnosed Threat to Older Adults’ Health
Vitamin B12 deficiency, common in older adults, is linked to cognitive decline, depressive symptoms, balance disturbances, gait disorders, sarcopenia, and frailty. Early supplementation can improve cognitive and physical health, suggesting routine screening and early intervention in high-risk older adults can preserve functional independence.
Vitamin B12 deficiency, common in older adults, is linked to cognitive decline, depressive symptoms, balance disturbances, gait disorders, sarcopenia, and frailty. Early supplementation can improve cognitive and physical health, suggesting routine screening and early intervention in high-risk older adults can preserve functional independence.
Multilingualism: A Protective Factor Against Accelerated Aging
Multilingualism is found to serve as a protective factor against accelerated aging in a comprehensive study of 86,149 participants across 27 European countries. Whereas monolingualism increased the risk of accelerated aging, results showed multilingualism delayed aging.
Multilingualism is found to serve as a protective factor against accelerated aging in a comprehensive study of 86,149 participants across 27 European countries. Whereas monolingualism increased the risk of accelerated aging, results showed multilingualism delayed aging.
Dietary Iron Positively Influences Epigenetic Aging and Extends Survival in Older Adults
Higher dietary iron intake is associated with favorable epigenetic profiles, reducing levels of mortality-predictive DNA methylation markers, and decreasing risk of all-cause mortality, heart disease mortality, and respiratory disease mortality in adults aged over 50. Optimizing iron intake could promote healthy aging.
Higher dietary iron intake is associated with favorable epigenetic profiles, reducing levels of mortality-predictive DNA methylation markers, and decreasing risk of all-cause mortality, heart disease mortality, and respiratory disease mortality in adults aged over 50. Optimizing iron intake could promote healthy aging.
🧬 Longevity + Science 🧪
Predictive Power of Brain Age Gap: Linking Aging, Lifestyle, and Neuropsychiatric Health
Brain age gap (BAG), a measure of accelerated brain aging, is predictive of neuropsychiatric disorders, cognitive decline, and mortality. Lifestyle interventions such as smoking cessation, moderate alcohol consumption, and physical activity can significantly slow BAG progression, particularly in individuals with advanced neurodegeneration.
Brain age gap (BAG), a measure of accelerated brain aging, is predictive of neuropsychiatric disorders, cognitive decline, and mortality. Lifestyle interventions such as smoking cessation, moderate alcohol consumption, and physical activity can significantly slow BAG progression, particularly in individuals with advanced neurodegeneration.
Wearable-based Aging Clock PpgAge: A New Tool in Longevity Research
Researchers have developed PpgAge, a wearable-based aging clock that measures photoplethysmography at the wrist. This tool accurately predicts chronological age and signs of healthy aging. An elevated PpgAge gap indicates higher diagnosis rates of heart disease, heart failure, and diabetes.
Researchers have developed PpgAge, a wearable-based aging clock that measures photoplethysmography at the wrist. This tool accurately predicts chronological age and signs of healthy aging. An elevated PpgAge gap indicates higher diagnosis rates of heart disease, heart failure, and diabetes.
TranslAGE: Revolutionizing the Validation of Epigenetic Aging Biomarkers
TranslAGE, a new platform for systematic validation of epigenetic aging biomarkers, combines multiple datasets and offers a standardized framework for comparing biomarker performance. The platform allows researchers to identify and validate biomarkers best suited to their scientific or clinical applications, accelerating their translation to clinical use.
TranslAGE, a new platform for systematic validation of epigenetic aging biomarkers, combines multiple datasets and offers a standardized framework for comparing biomarker performance. The platform allows researchers to identify and validate biomarkers best suited to their scientific or clinical applications, accelerating their translation to clinical use.
🧬 Real-time Age Quantification in Living Systems: Fluorescence Lifetime Clocks Quantify Senescence and Aging
New fluorescence lifetime imaging strategy allows real-time age quantification in living systems, offering an invaluable tool for aging biology research and translation. This approach relies on shifts in rRNA species associated with aging and cellular senescence, and has been successfully tested in cells, tissues, and in organisms like C. elegans, mice, and humans.
New fluorescence lifetime imaging strategy allows real-time age quantification in living systems, offering an invaluable tool for aging biology research and translation. This approach relies on shifts in rRNA species associated with aging and cellular senescence, and has been successfully tested in cells, tissues, and in organisms like C. elegans, mice, and humans.
Introducing LifeClock: A Biological Clock for All Life Stages
The article introduces LifeClock, a biological clock model that predicts biological age across all life stages using electronic health records and lab data. The model distinguishes pediatric development from adult aging and accurately predicts risks of major age-related diseases.
The article introduces LifeClock, a biological clock model that predicts biological age across all life stages using electronic health records and lab data. The model distinguishes pediatric development from adult aging and accurately predicts risks of major age-related diseases.
EpiClock: A New Biological Age Measurement Tool Using DNA Methylation
EpiClock, a new biological age measurement tool, uses a minimal set of CpG markers for high-throughput iPlex mass spectrometry assays. The model shows high correlation between DNA methylation levels and biological age, demonstrating potential for screening in drug development and population health studies.
EpiClock, a new biological age measurement tool, uses a minimal set of CpG markers for high-throughput iPlex mass spectrometry assays. The model shows high correlation between DNA methylation levels and biological age, demonstrating potential for screening in drug development and population health studies.
🐁 Unraveling the Role of Metabolite Sensor CtBP2 in Lifespan Extension
Metabolite sensor CtBP2, secreted via exosomes, extends lifespan and improves healthspan in aged mice by reducing frailty and activating CYB5R3 and AMPK. Decreasing CtBP2 levels correlate with aging and cardiovascular disease in humans, but are higher in longevity families.
Metabolite sensor CtBP2, secreted via exosomes, extends lifespan and improves healthspan in aged mice by reducing frailty and activating CYB5R3 and AMPK. Decreasing CtBP2 levels correlate with aging and cardiovascular disease in humans, but are higher in longevity families.
Frailty Tied to GrimAge Epigenetic-Age Acceleration: Meta-Analysis
A meta-analysis reveals that higher GrimAge epigenetic-age acceleration (EAA) is consistently associated with higher frailty, an age-related multisystem physiological decline. This association emphasizes the potential of DNA methylation clocks in early identification of individuals at risk of frailty, enabling early interventions.
A meta-analysis reveals that higher GrimAge epigenetic-age acceleration (EAA) is consistently associated with higher frailty, an age-related multisystem physiological decline. This association emphasizes the potential of DNA methylation clocks in early identification of individuals at risk of frailty, enabling early interventions.
Unified Framework for Aging Biomarkers: Horvath Clocks and GrimAge2 Leading the Way
The study reveals the Horvath skin and blood clock as the most accurate in chronological age prediction, while GrimAge2 showed the strongest mortality and healthspan prediction. The study also suggests that traditional aging clocks’ ability to predict chronological age doesn’t correlate with mortality prediction capacity.
The study reveals the Horvath skin and blood clock as the most accurate in chronological age prediction, while GrimAge2 showed the strongest mortality and healthspan prediction. The study also suggests that traditional aging clocks’ ability to predict chronological age doesn’t correlate with mortality prediction capacity.
🧑🤝🧑 Longevity + Teams 📰
Roadmap for Biogerontology: 100 Open Problems in Ageing Science
The article presents a collection of 100 open problems in ageing and longevity science, gathered through community engagement and Natural Language Processing analysis. The list aims to highlight key research questions in ageing biology and guide future progress in biogerontology.
The article presents a collection of 100 open problems in ageing and longevity science, gathered through community engagement and Natural Language Processing analysis. The list aims to highlight key research questions in ageing biology and guide future progress in biogerontology.
Revolutionizing Biology with AI: A Discussion with Mark Zuckerberg and Priscilla Chan
Mark Zuckerberg and Priscilla Chan discuss the application of AI in solving complex scientific problems, particularly in biology. They emphasize the potential of AI in revolutionizing biological research, with an emphasis on the ‘Biohub’ project, which focuses on creating a unified AI-based virtual cell model and studying the Virtual Immune System.
Mark Zuckerberg and Priscilla Chan discuss the application of AI in solving complex scientific problems, particularly in biology. They emphasize the potential of AI in revolutionizing biological research, with an emphasis on the ‘Biohub’ project, which focuses on creating a unified AI-based virtual cell model and studying the Virtual Immune System.
88 Innovators Recognized by NAM for Bold Ideas in Healthy Longevity
The National Academy of Medicine (NAM) announced the recipients of the 2025 Healthy Longevity Catalyst Awards, recognizing 88 innovators with $50,000 each for their transformative ideas in extending human healthspan. The competition will advance to the Grand Prize phase in 2026.
The National Academy of Medicine (NAM) announced the recipients of the 2025 Healthy Longevity Catalyst Awards, recognizing 88 innovators with $50,000 each for their transformative ideas in extending human healthspan. The competition will advance to the Grand Prize phase in 2026.
AI Agents Break Through Longevity Research Barriers
An international hackathon, Hackaging.ai, used AI agents to address the major bottlenecks in longevity research: limited funding, a small talent base, scarce data, and low public awareness. The initiative has already attracted new talent into the field.
An international hackathon, Hackaging.ai, used AI agents to address the major bottlenecks in longevity research: limited funding, a small talent base, scarce data, and low public awareness. The initiative has already attracted new talent into the field.
💡Featured Article 🌟
The study explores the concept of the Brain Age Gap (BAG), a neuroimaging-derived marker that measures the difference between an individual’s estimated brain age and their chronological age. This marker is gaining attention for its potential to predict risks associated with cognitive decline, neuropsychiatric disorders, and mortality. Utilizing data from over 40,000 participants across three major cohort studies (UK Biobank, ADNI, and PPMI), the researchers employed a 3D Vision Transformer model to estimate brain age with a mean error of approximately 2.68 to 3.20 years.
The findings reveal that each one-year increase in BAG correlates with a 16.5% increased risk of Alzheimer’s disease, a 4.0% increased risk of mild cognitive impairment, and a 12% increase in all-cause mortality risk.
The study highlights that individuals in the highest risk group (Q4) exhibit significantly elevated risks for Alzheimer’s disease, multiple sclerosis, and mortality, with cognitive decline most pronounced in reaction time and processing speed. Importantly, lifestyle interventions such as smoking cessation, moderate alcohol consumption, and regular physical activity were shown to significantly slow the progression of BAG, particularly in individuals with advanced neurodegeneration.
🍫Cocoa slows aging, 👶Pregnancy ages mom, 🏃♂️Athlete EVs heal
December 16, 2025
Longevity Signals ⏳Longevity Signals📈 December 16, 2025 Welcome to Longevity Signals, a briefing brought to you by the Clock Foundation. Each week, we hunt for
🧠 Multilingualism delays aging, 🕰️ Horvath clocks lead, 🧬 NR’s weak effects
November 18, 2025
Longevity Signals ⏳Longevity Signals📈 November 18th, 2025 Welcome to Longevity Signals, a briefing brought to you by the Clock Foundation. Each week, we hunt for
🐭❤️ Oxytocin combo extends life, 💊 NMN returns, 🐛 Dauer decoded
October 21, 2025
Longevity Signals ⏳Longevity Signals📈 October 21, 2025 Welcome to Longevity Signals, a briefing brought to you by the Clock Foundation. Each week, we hunt for