⏳Longevity Signals📈
May 28, 2025
Note: This is not medical advice. Please consult your physician before making changes to your health routine.
🩺 Longevity + Treatments 💪
The VITamin D and OmegA-3 TriaL (VITAL) reveals that supplementation with Vitamin D3 and marine ω-3 fatty acids over four years can affect leukocyte telomere length, a key marker of biological aging.
Consuming foods categorized as methyl adaptogens such as green tea, oolong tea, turmeric, rosemary, garlic, berries can reduce markers of epigenetic aging, independent of weight changes, as revealed by a secondary analysis of the Methylation Diet and Lifestyle study.
AI-driven analysis of geroprotective compounds reveals polypharmacological compounds, which bind multiple biogenic amine receptors, are the most effective lifespan-extenders in Caenorhabditis elegans. Over 70% of selected polypharmacological compounds extended lifespan significantly.
Christian J. Elliehausen’s dissertation evaluates the impact of geroprotective interventions, such as Rapamycin and Metformin, on musculoskeletal and metabolic systems. The research finds these drugs can potentially enhance healthy longevity by attenuating skeletal muscle transcriptional and mitochondrial respiratory adaptations to exercise.
Numerous interventions show potential for promoting remyelination. Despite limitations such as short follow-up periods, interventions like rHIgM22, L-T3, opicinumab, clemastine fumarate, and low-intensity repetitive TMS have shown promising effects. The focus is treatment of multiple sclerosis but there is potential they could be repurposed for cognitive aging.
🧬 Longevity + Science 🧪
The study introduces EPI-Clone, a method for accurate, transgene-free lineage tracing, applied to mouse and human haematopoiesis. It reveals that in ageing, a small number of expanded clones show myeloid bias and low output, while many young-like clones persist.
The gut-vitamin D axis plays a crucial role in mitigating immunosenescence and preventing chronic inflammation and age-related diseases. Both gut microbiota dysbiosis and vitamin D insufficiency can accelerate immunosenescence and increase the risk of chronic diseases. Vitamin D regulates gut microbiota diversity and composition, enhances immune resilience, and reduces systemic inflammation.
CMImpute, a method based on a conditional variational autoencoder, has been developed for imputing DNA methylation representing species-tissue combinations. It effectively correlates imputed and observed values, offering methylation data for 19,786 new species-tissue combinations, a useful resource for DNA methylation analyses.
Mitochondrial RNA profiling across 47 human tissues revealed two distinct tissue-specific aging signatures. Tissues with constant cellular turnover (like the skin or gut) show accelerated mutation accumulation, while post-mitotic tissues (like the heart and brain) show mutations at deterministic hotspots. These findings support a biphasic model of the mitochondrial aging clock and offer potential therapeutic targets.
🧑🤝🧑 Longevity + Teams 📰
The first Enhanced Games, to be held in May 2026, will allow athletes using performance-enhancing drugs such as testosterone, growth hormone, and certain anabolic steroids to compete, potentially demonstrating the effects of science on human physical capabilities.
San Francisco’s 16-story Frontier Tower is being repurposed to host longevity researchers, biohackers, and neurotech developers for a six-week residential program. The initiative aims to foster collaboration and faster iteration in the longevity field, addressing the inertia often found in institutional research.
FDA has successfully completed its first AI-assisted scientific review pilot, with an aggressive timeline to scale AI use agency-wide by June 30, 2025. This could accelerate review time for new therapies by automating tedious, repetitive tasks.
The Longevity Investor Network (LIN) saw significant growth in 2024, doubling its investor membership and investing over $650,000 in six innovative longevity biotech startups. These companies are developing treatments for age-related diseases and aim to extend human healthspan.
💡Featured Article 🌟
The study “Mitochondrial clonal mosaicism encodes a biphasic molecular clock of aging” explores the role of mitochondrial mutations as a molecular clock for aging and disease. Researchers profiled mitochondrial RNA from 47 human tissues across 838 individuals, identifying two distinct aging signatures: one in tissues with constant cellular turnover (like the gastrointestinal tract and skin) and another in post-mitotic tissues (such as the heart and brain). This biphasic model suggests that proliferative tissues experience stochastic clonal expansion of sporadic replication errors, while high-metabolic tissues accumulate age-dependent heteroplasmy at deterministic hotspots. Mitochondria, the energy powerhouses of cells, have a high mutation rate due to their unique DNA structure and replication processes. These mutations, which accumulate over a lifetime, can serve as sensitive indicators of aging and tissue-specific vulnerabilities. The study highlights the dynamic nature of mitochondrial clonal diversity (heteroplasmy) and its impact on aging and disease, particularly in high-energy-demanding tissues linked to conditions like Alzheimer’s, Parkinson’s, macular degeneration, diabetes, and heart disease.
The findings underscore the potential of targeting mitochondrial dysfunction as a therapeutic strategy. By understanding the tissue-specific dynamics of mitochondrial mutations, interventions could be developed to mitigate age-related damage and improve longevity. For individuals interested in longevity, this research suggests focusing on maintaining mitochondrial health through lifestyle choices that minimize oxidative stress and support efficient mitochondrial function. This could include dietary interventions, exercise, and potentially novel therapies targeting mitochondrial biogenesis and turnover processes. Overall, the study provides a comprehensive map of mitochondrial mutations across different tissues, offering insights into the molecular underpinnings of aging and highlighting potential avenues for therapeutic intervention to enhance human health and longevity.
🧬 CRISPR concerns⚠️, Anti-aging meds 💊, Shift’s breakthrough 🌟
Longevity Signals ⏳Longevity Signals📈 June 17, 2025 Welcome to the 5th edition of Longevity Signals, a briefing brought to you by the Clock Foundation. Each
🍳 Keto diet debated 🔍, Sleep slows age 💤, GrimAge predicts AD 🧓
Longevity Signals ⏳Longevity Signals📈 June 3, 2025 Welcome to the 4th edition of Longevity Signals, a briefing brought to you by the Clock Foundation. Each
🏋️ Enhanced Games excitement, 🧬 Mito clock decoded, 🤖 FDA AI rollout
Longevity Signals ⏳Longevity Signals📈 May 28, 2025 Welcome to the 3rd edition of Longevity Signals, a briefing brought to you by the Clock Foundation. Each
