⏳Longevity Signals📈
June 17, 2025
Note: This is not medical advice. Please consult your physician before making changes to your health routine.
🩺 Longevity + Treatments 💪
CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells can lead to unintended consequences such as senescence and inflammation.
A study using data from the Baltimore Longitudinal Study of Aging found that five drug categories—Vitamin D, bisphosphonates, proton pump inhibitors, thyroid hormones, and thiazides—were associated with significant reductions in phenotypic aging markers, suggesting potential protective effects of these medications on aging.
The article presents a novel factor that can potentially make cellular rejuvenation safer. This factor, when further explored, could revolutionize preventive medicine and contribute to human longevity.
Prostaglandin E2 has been found to reverse the dysfunction of aged muscle stem cells, leading to improved muscle regeneration and strength, according to a multiomic profiling study.
Adherence to healthy lifestyle behaviors is linked to reduced epigenetic aging, according to a study on middle-aged and older adults. The research highlights the potential of lifestyle modifications as a strategy for mortality risk mitigation and emphasizes the utility of epigenetic clocks in precision gerontology.
🧬 Longevity + Science 🧪
Researchers have developed an epigenetic predictor of intrinsic capacity (IC), a sum of an individual’s physical and mental capacities, using DNA methylation data. This ‘IC clock’ outperforms first and second-generation epigenetic clocks in predicting mortality and is associated with immune markers, health risk factors, and lifestyle choices.
Josh Mitteldorf reviews how methylation clocks, used for testing anti-aging interventions, rely on distinguishing ‘Type 1’ changes (body destroying itself) from ‘Type 2’ changes (body repairing itself). Only Type 1 changes are useful in these clocks, posing a challenge for epigenetic clock developers.
Regular exercise inhibits aging in intestinal stem cells (ISCs), maintaining intestinal homeostasis. Exercise upregulates signaling pathways related to DNA replication and cell cycle progression in ISCs, recovers Wnt signaling inhibition, and improves gut barrier function.
Targeting DNA damage has become a promising strategy to combat ageing and prevent age-related diseases. Recent advances focus on enhancing DNA repair capacities and mitigating the adverse effects of DNA damage to prolong lifespan and healthspan.
Biological age is linked to dementia risk and cognitive function decline, according to a study from the UK Biobank. The study found individuals with older biological ages had increased dementia risk and worse cognitive performance.
🧑🤝🧑 Longevity + Teams 📰
Shift Bioscience has identified a novel single-gene target, SB000, for safer cellular rejuvenation therapies. SB000 can reverse cellular aging across multiple cell types without inducing dangerous pluripotency pathways, thus overcoming limitations of existing approaches that primarily focus on Yamanaka Factors.
Kejun Ying from Vadim Gladyshev’s lab has presented a doctoral thesis titled ‘On the Quantification of Aging’. His impressive thesis work focuses on epigenetic aging clocks.
Rentosertib, an AI-generated inhibitor of TNIK, demonstrated safety and efficacy in a phase 2a trial for idiopathic pulmonary fibrosis (IPF), an age-related progressive lung condition. The trial showed increased lung function at the highest dosage, supporting further investigation in larger-scale clinical trials.
Researchers are using regenerative medicine and AI to identify drug combinations that target multiple age-related biological pathways simultaneously. Techniques include rejuvenating cells with engineered adeno-associated viruses (AAV) and transplanting precursor stem cells. The article describes research from several companies targeting age-related diseases.
💡Featured Article 🌟
The study explores the impact of common medications on phenotypic aging (PA) markers. Utilizing data from the Baltimore Longitudinal Study of Aging (BLSA), the research investigates how 27 drug categories influence four domains of PA: body composition, energetics, homeostatic mechanisms, and neuroplasticity/neurodegeneration. The study uses conditional generalized estimating equations (cGEE) to analyze within-individual variations, effectively controlling for genetic and early-life factors. This approach provides a robust framework for understanding how medication use correlates with changes in PA markers.
Key findings reveal that five drug categories are associated with significant reductions in PA markers, suggesting potential protective effects against aging. Vitamin D, bisphosphonates, and proton pump inhibitors (PPIs) were linked to improvements in body composition, energetics, and neuroplasticity/neurodegeneration, respectively. Thyroid hormones showed benefits in body composition and neuroplasticity/neurodegeneration, while thiazides were associated with improvements across body composition, energetics, and homeostatic mechanisms.
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