Epigenetic GrimAge Test (Analysis Only)

Biological age refers to your age on a biological level compared to your chronological age or how many birthdays have passed for you. 

Biological age tests look at changes in your biology that are indicative of biological aging. In our case, our biological age test uses what is called an epigenetic clock to calculate your biological age.  

Fortunately, your biological age is modifiable, meaning you can change it. Tracking your biological age can help you see changes over time and understand the impact diet, lifestyles changes, and anti-aging treatments are having on your rate of aging.

Both tests determine biological age and associated risks.

PhenoAge is calculated using levels of 9 clinical biomarkers circulating in blood, which were found to strongly correlate with onset of age-related diseases and mortality.

GrimAge Test is an epigenetic test and predicts your biological age based on DNA methylation, basically changes in your DNA over time. GrimAge is the “gold standard” in longevity research offers and offers personalized aging drivers, risk factors and tailored recommendations for longevity.

PhenoAge Test involves a blood (plasma) lab test and takes just a few days to get your results, while a GrimAge involves an at-home blood collection kit, which you ship back to our lab for processing, DNA extracting and sequencing, and report processing. GrimAge takes a few weeks to complete and get your report.

After ordering a single test or a package, you’ll receive a welcome email detailing how our program works and the steps ahead.

For U.S. participants, this initial email will include:

1. A link to an online survey to register your test kit and complete a brief intake questionnaire;
2. A form that enables you to obtain your first blood draw, along with instructions on how to schedule an appointment; and
3. Instructions on how to collect and return your at-home blood collection kit.

For a PhenoAge Test, you will receive your initial test report including your  results as soon as each of the above steps have been completed (within approximately 1 week). Once you receive your initial results, you’ll also be able to book a 1-on-1 consultation with our team to discuss.

Results of our advanced Epigenetic Test are usually available within 4-6 weeks. 

Our subscription and longevity biomarker plans combine the two biological aging tests used by longevity researchers with wearable monitoring, providing cutting-edge longevity intervention tracking and aging monitoring.

Our wearables monitoring plan integrates with Oura, FitBit, Google, Garmin and an assortment of health trackers. Data is sync regularly and you’ll receive a personal month report proving HRV Age as well as sleep, activity and other aging metric.

You’ll receive access to our longevity tracking portal to review and monitor your health data and reports as well as tools to track and manage your longevity interventions and actions.

Cancellations are accepted at anytime, but in order to obtain test results from a submitted sample, it requires having an active subscription for at least 2 months to cover costs.

We currently only ship to the United States, UK and Europe and serviced by labs in Los Angeles, USA, and Manchester, UK.

Please contact us if you are located elsewhere and are still interested in purchasing a test or participating in an anti-aging trial.

A genetic or DNA test looks at what your DNA contains whereas an epigenetic age test measures various epigenetic changes on our DNA itself. Unlike DNA, your epigenetics are modifiable.

Many cells in the body have an “epigenetic clock” that keeps track of how quickly they are aging or, more accurately, how much damage has been done since they were created.

Our test provides your biological age as well as various key drivers of your aging.

Our tests are based on epigenetic data. Unfortunately we are not able to compute GrimAge based from genetic data provided by Ancestry or 23&Me.  We require epigenetic data and specifically IDAT files provided by epigenetic test providers.  There are many service labs around the world who provide this type of service using testing provided by Illumina methylation arrays (such as the EPIC methylation beadchip)

Longevity Groups are participatory research initiatives facilitated by the Clock Foundation. These groups allow individuals to collectively explore the effects of various anti-aging treatments, supplements, and protocols. Participants track their biological age and other biomarkers to help generate reliable data on the effectiveness of different interventions.

Learn more and signup here.

Epigenetics is the study of how genes are turned off and on during an animal’s lifetime, including humans. 

A Greek word meaning “above genetics”, epigenetics is the study of changes in gene function that occur without detectable changes to DNA sequence. What this means is that your gene expression (like what proteins your cells produce) changes but your gene sequences themselves do not change. 

Epigenetics most often involves changes that affect gene activity and expression. These epigenetic changes can occur due to normal biological development but they can also result from external or environmental factors like food choices, stress levels or even injury.

DNA methylation is a process where methyl groups are added to DNA to influence gene expression, and which are critical for normal human development, defining cell identity, as well as for rejuvenation and reprogramming.  Highly accurate estimators of chronological age have been developed are known as epigenetic aging clocks, which can predict chronological age through development and across the lifespan (Horvath 2013, Horvath & Raj 2018). 

Increasingly these clocks are also being used as a measure of biological age as certain measures – most notably GrimAge (Lu 2019, Li 2020), which is able to predict future morbidity and mortality risk.  GrimAge also performs well for predicting functional decline and onset of major age-related diseases, including heart disease, cancer onset, multi-modal measures of brain health, kidney disease, fatty liver, respiratory function, and more (Lu 2019, Hillary 2018, Hillary 2020, McCrory 2020). These peer reviewed and independent studies have also shown that it performs reliably across large diverse populations.  

Many researchers conclude today that overall epigenetic clocks now represent the most robust measure of biological age (Li 2020, Jylhava et al 2017, Justice & Kritchevsky 2020).